Genmodifiering embryon
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You are using a browser version with limited support for CSS. To obtain the best genmodifiering embryon, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. An Author Correction to this article was published on 10 December With the advent of efficient, easy-to-use genome editing by CRISPR—Cas9, editing human embryos is now possible, providing tremendous opportunities to study gene function and cell fate in early human development.
The technique can also be used to modify the human germline.
Rätt sätt att genförändra människor
In this Perspective, we discuss genmodifiering embryons in human genome editing and consider ethical questions and potential clinical implications of this technology. This is a preview of subscription content, access via your institution. An amendment to this paper has been published and can be accessed via a link at the top of the paper. Cong, L. Science— Jinek, M. RNA-programmed genome editing in human cells.
Mali, P. RNA-guided human genome engineering via Cas9.
Human germline genome editing
Adli, M. Carroll, D. Genome engineering with zinc-finger nucleases. Genetics— Joung, J. TALENs: a widely applicable technology for targeted genome editing. Cell Biol. Silva, G. Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy. Gene Ther. Gasiunas, G. Natl Acad.
Beyond gene-edited babies: the possible paths for tinkering with human evolution
USAE—E Liang, P. Protein Cell 6— Kang, X. Tang, L. Genomics— Joergensen, M. Altered cleavage patterns in "genmodifiering embryon" tripronuclear embryos and their association to fertilization method: a time-lapse study. Lammers, J. Morphokinetic parameters of ICSI tripronucleated embryos observed using time lapse. Online 28— PubMed Google Scholar. Yao, G.
Developmental potential of clinically discarded human embryos and associated chromosomal analysis. Ma, H. Correction of a pathogenic gene mutation in human embryos. Nature— Safari, F.